The research pioneers

Pioneer of anti-cancer nutrition science. His laboratory demonstrated that a cocktail of 9 plant foods could significantly slow tumor progression in animal models with no functional immune system — proving that phytochemicals act directly on cancer mechanisms, independently of immunity.

Long-time collaborator of Dr Béliveau, co-author of numerous key publications on cruciferous vegetables, berries and tumor angiogenesis. His work on VEGF and PDGF receptor inhibition by natural compounds is foundational to the science of anti-cancer nutrition.

Demonstrated that curcumin can reverse resistance to paclitaxel (Taxol) in breast cancer cells by targeting NF-kB, opening the door to combining plant compounds with conventional chemotherapy. His work on NF-kB as a central target of phytochemicals has been highly influential.

Published in Nature (2001) that EGCG from green tea is one of the most potent anti-angiogenic compounds identified to date, capable of inhibiting tumor blood vessel growth at physiologically achievable concentrations. This discovery is the scientific basis for recommending 3-5 cups of green tea per day.

Work on ellagic acid and anthocyanins in berries showing their ability to block multiple pathways simultaneously — including NF-kB, angiogenesis and apoptosis — illustrating the "multi-target" principle that distinguishes phytochemicals from single-target drugs.